Applications

Astrego’s technology offers fast, sensitive, and precise Antibiotic Susceptibility Testing (AST) in a completely automated fashion making it a candidate for replacing the current methodology in central laboratories.

With unmatched speed at low cost, the technology is also applicable to near patient testing, enabling evidence-based antibiotic prescription for a vast number of conditions, such as Urinary and Respiratory Tract Infections, Tuberculosis, Skin Infections and Sterile Body Fluid Infections (i.e. Sepsis, Meningitis, Infectious Arthritis).

Astrego’s technology can be applied to samples at all stages of the clinical microbiology workflow:

AST for Urinary Tract Infections in minutes

Astrego´s qUTI system (under development) comprises a desk-top instrument and single-use disposable cartridges preloaded with a panel of antibiotics for rapid detection of bacterial infection and susceptibility testing for UTI patients at the Point of Care. On the bottom of the Technology page there is a movie clip demonstrating the qUTI system.

The system reports the presence of growing bacteria in urine samples within 10 minutes. If the urine culture is positive, the system automatically performs a susceptibility test and the category Susceptible (S) or Resistant (R) is reported in a total turn-around-time of less than 30 minutes. Thus, it enables evidence-based treatment for UTI-patients at their first consultation.

AST for Bacterial blood stream Infections

Sepsis is one of the most common reasons for admission to a critical care in the US and in Europe and a major cause of death worldwide. To reduce the mortality and the cost of care it is critical to treat sepsis patients with the right antibiotic as fast as possible.

The number of bacteria can be very low in blood stream infections, thus blood cultures are performed to increase the numbers to detectable levels. Astrego’s technology captures bacteria from positive blood cultures within a few seconds and provides AST in minutes.

AST for Bacterial blood stream Infections

Bacterial blood stream infections is a common cause of sepsis, which is one of the most common reasons for admission to critical care in the US and in Europe and a major cause of death worldwide. To reduce the mortality and the cost of care it is critical to treat sepsis patients with the right antibiotic as fast as possible.

The number of bacteria can be very low in a blood steam infection, thus blood cultures are performed to increase the numbers to reach detectable limits. Astrego’s technology can capture bacteria from positive blood cultures within a few seconds and can provide AST within minutes, not hours.

General AST for any bacterial infection

Pathogens from patient samples containing natural flora often need to be isolated and identified before AST can be performed. This usually takes 1-2 days and is performed in the clinical microbiology laboratory by plating and identifying individual colonies on the plate. Subsequently, AST of the bacterial isolates takes another 16 hours in the conventional workflow (or up to 4 weeks for Tuberculosis).

Astrego’s technology enables AST to be performed directly from isolated colonies in less than 1/10 of the time compared to standard methods.

Benefits

Healthcare System

A highly requested and currently unavailable diagnostic tool for evidence based management of infections.

Improved monitoring of local, regional or global antibiotic resistance.

Pharma Industry

Extend life-time of primary antibiotics beyond 20% resistance.

Efficient tool for product development and clinical evaluation of new antibiotics.

Patient

Always correct diagnosis and immediate prescription of optimal antibiotic.

Reduced discomfort and less side effects from use of broad spectrum antibiotics.

Reduced risk of severe complications due to untreated infections.

Society

Accurate diagnosis of bacterial infection avoids misuse of antibiotics.

Reduces risk for antibiotic resistance development.

Fewer sick-days – lower cost